du Preez, Ryan (2015) Cyanidin 3-glucoside in diet-induced metabolic syndrome in rats. Honours thesis, University of Southern Queensland. (Unpublished)
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Abstract
Metabolic syndrome combines the risk factors for type 2 diabetes and cardiovascular disease, including obesity, insulin resistance, impaired glucose tolerance, dyslipidaemia and hypertension. Obesity is now understood to be a chronic low-grade inflammatory state with sustained oxidative stress. There are few drug therapies for obesity and all may produce unacceptable adverse effects. Thus, functional foods may serve as a better alternative for treatment of metabolic syndrome. Anthocyanins are purple-coloured polyphenolic compounds found in dark-coloured fruits and vegetables, such as purple carrot, Queen Garnet plum, chokeberry and purple corn. As anthocyanins produce anti-oxidant and anti-inflammatory responses, this study investigated whether anthocyanin-rich black rice can reverse the signs of diet-induced metabolic syndrome. This study used high-carbohydrate, high-fat diet-fed male Wistar rats to mimic the symptoms of human metabolic syndrome. Rats developed hypertension, diabetes along with damage to cardiovascular and hepatic systems. However, rats supplemented with cyanidin 3-glucoside rich black rice extract mid-way through the protocol had noticeable overall health improvements. Black rice extract reversed many changes the rats developed while on the diet including reduced body weight (10%), abdominal obesity (6%) and normalising systolic blood pressure; improved hepatic structure (decreased inflammation) and function; (decreased liver enzyme activity) improved cardiovascular structure (decreased inflammation and fibrosis) and function along with reduced overall cholesterol and decreased liver enzyme activity.
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| Item Type: | Thesis (Non-Research) (Honours) |
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| Item Status: | Live Archive |
| Additional Information: | Bachelor of Science (Honours) thesis. |
| Faculty/School / Institute/Centre: | Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021) |
| Supervisors: | Panchal, Sunil; Brown, Lindsay |
| Date Deposited: | 22 Dec 2015 01:40 |
| Last Modified: | 10 Jul 2019 01:51 |
| Uncontrolled Keywords: | diet-induced metabolic syndrome, anthocyanin, cyanidin 3-glucoside, obesity, Queen Garnet plum, purple carrots |
| Fields of Research (2008): | 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology |
| Fields of Research (2020): | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science |
| URI: | https://sear.unisq.edu.au/id/eprint/28263 |
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